The possible constitutive activity of wild-type angiotensin II type 1 receptor
نویسندگان
چکیده
منابع مشابه
Angiotensin II type 1 receptor blockers.
In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1,2 Thereafter, the development of pharmacological probes that block the renin-angiotensin system helped def...
متن کاملConstitutive activation of angiotensin II type 1 receptor alters the orientation of transmembrane Helix-2.
A key step in transmembrane (TM) signal transduction by G-protein-coupled receptors (GPCRs) is the ligand-induced conformational change of the receptor, which triggers the activation of a guanine nucleotide-binding protein. GPCRs contain a seven-TM helical structure essential for signal transduction in response to a large variety of sensory and hormonal signals. Primary structure comparison of ...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy.
Angiotensin II (Ang II) has important actions on the heart via type 1 (AT1) and type 2 (AT2) receptors. The link between AT1 receptor activation and the hypertrophy of cardiomyocytes is accepted, whereas the contribution of the AT2 receptor, which reportedly antagonizes the AT1 receptor, is contentious. This ambiguity is primarily based on in vivo approaches, in which the direct effect of the A...
متن کاملeffect of angiotensin ii type 1 receptor antagonist, losartan on inflammatory factor in atherosclerotic rabbits
materials and methods: 32 new zealand rabbits were randomly divided into three groups: control group, high-cholesterol group and losartan group. the level of weights, serum lipid levels and inflammatory factors, such as il-6 and hs c-reactive protein were detected before the losartan intervention and two months after the losartan intervention respectively. the content of angii was detected on l...
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ژورنال
عنوان ژورنال: Hypertension Research
سال: 2014
ISSN: 0916-9636,1348-4214
DOI: 10.1038/hr.2014.61